One-Pot Multicomponent Domino Synthesis of 4-Aminothiazole-2(3H)-thiones
نویسندگان
چکیده
منابع مشابه
An efficient one-pot synthesis of 2-aminothiazole derivatives
A highly efficient, rapid and catalyst free protocol has been developed for the synthesis of 2-aminothiazoles in tetrahydrofuran (THF). Reaction was carried out at room temperature and the products were obtained in high yields without further purification.
متن کاملA straightforward one-pot multicomponent synthesis of polysubstituted pyrroles.
Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.
متن کاملOne-pot chemoenzymatic multicomponent synthesis of thiazole derivatives.
A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards d...
متن کاملAsymmetric Synthesis of Tetrahydropyridines via an Organocatalytic One-Pot Multicomponent Michael/Aza-Henry/Cyclization Triple Domino Reaction
A low loading of a quinine-derived squaramide efficiently catalyzes the triple-domino Michael/aza-Henry/cyclization reaction between 1,3-dicarbonyl compounds, β-nitroolefins, and aldimines to provide tetrahydropyridines bearing three contiguous stereogenic centers in good yields, excellent enantiomeric excesses, and up to high diastereomeric ratios.
متن کاملMulticomponent versus domino reactions: One-pot free-radical synthesis of β-amino-ethers and β-amino-alcohols
Following an optimized multicomponent procedure, an aryl amine, a ketone, and a cyclic ether or an alcohol molecule are assembled in a one-pot synthesis by nucleophilic radical addition of ketyl radicals to ketimines generated in situ. The reaction occurs under mild conditions by mediation of the TiCl4/Zn/t-BuOOH system, leading to the formation of quaternary β-amino-ethers and -alcohols. The n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Synlett
سال: 2014
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0034-1378922